Comparative Study between Bone Marrow- mesenchymal Stem Cells and Adipose Tissue- mesenchymal Stem Cells in Restoration of Male Fertility

Background: Male infertility is considered a major cause of couple as it represents 25- 50 % cases. In addition, non-obstructive azoospermia (NOA) 10% all infertile men.There no definite curable treatment for such cases.
 Aim Work: The purpose this research was to assess the efficacy BM-MSCs and AT-MSCs in treating busulfan-induced wistar rats.
 Materials Methods: were extracted from femur bones five adult Wistar rats preperitoneal adipose tissue. They then evaluated morphology, MSC markers, osteogenic adipogenic differentiation. To produce male rats, two doses busulfan (15 mg/kg 30 mg/kg) administered intraperitoneally during 21-day period. seminiferous tubules each testis injected with 2.5106 MSCs 35 days after second injection. 12 weeks cell therapy, testes examined histopathologically histomorphometrically.
 Results: Like control group, treated demonstrated normal spermatogenesis compared azoospermic testes. contrast testes, exhibited practically typical look spermatogenesis.
 Conclusion: shown be beneficial rat model, restoring fertility animals transplantation. As result, discovery may pave way future use human azoospermia, although more should conducted confirm findings.